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4.6
Rated 4.6 out of 5 stars
179 Reviews

Berberine HCI 90 Day Supply

BALANCE BURN REGULATE
$126.00
$177.00 $126.00
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01

AMPK Activation

Triggers the same metabolic pathway as exercise and fasting.*

02

Glucose & Lipid Support

Helps regulate blood sugar and cholesterol metabolism.*

03

Dual-Source Extract

Bark + root for a broader spectrum of active alkaloids.*

60-day risk-free guarantee. Free US shipping $100+.
INGREDIENTS

Berberine HCl · 1200mg
Dual-source extract from Berberis aristata bark + root for a broader spectrum of active alkaloids.*

WHY DUAL-SOURCE?

Single-source berberine misses half the picture. Our bark + root extract delivers complementary alkaloids for better absorption and stronger metabolic activity.*

Quality Standards

Delivery
Ships Out Next Business Day · Free Insured Shipping on $100+

Quality
Made in USA · GMP-Certified · 3rd-Party Tested

Standards
Non-GMO · Keto-Friendly · Gluten-Free · No Artificial Fillers

Guarantee
60-Day Money-Back Guarantee

GQ Vogue Forbes Well+Good WWD GQ Vogue Forbes Well+Good WWD GQ Vogue Forbes Well+Good WWD
Select Supply

Your Metabolic Protocol

Berberine benefits compound with 90+ days of consistent use

Best Value
Berberine - 6 Bottles
180 Day Supply

6 Bottles

$191 $294 Save $103
$32/bottle $49/bottle

60-Day Money-Back Guarantee · Free Shipping on Orders $100+

AMPK Activation

6 Core Benefits

Berberine activates the same metabolic pathways as exercise and fasting—without the sweat.*

01

Blood Sugar Support

02

Metabolic Activation

03

Lipid Balance

04

Weight Management

05

Gut Health

06

Cellular Energy

01

Blood Sugar Support

AMPK Pathway • Glucose Uptake

Berberine enhances insulin sensitivity and promotes glucose uptake into cells. Studies show it can support healthy blood sugar levels already within normal range—comparable to some pharmaceutical interventions.*

30+ Clinical Studies

The Science

AMPK

metabolic master switch

Berberine activates AMPK—the same pathway triggered by exercise and fasting. This regulates glucose uptake, fat metabolism, and cellular energy.*

30+

Clinical Studies

1,200mg

Clinical Dose

2x

Source Extracts

4-8wks

To See Results

*Based on published research on berberine and metabolic health

What's Inside

Dual-Source, Clinical Dose

1,200mg

Berberine HCl

Dual-source extract from Berberis aristata bark + root for a broader spectrum of active alkaloids. Activates AMPK to support glucose metabolism, lipid balance, and cellular energy.*

Quality Promise

Purity & Potency Guaranteed

Certified GMP Facility
  • GMP Certified Facility

    Manufactured in a facility that meets FDA Good Manufacturing Practice standards.

  • Third-Party Tested

    Every batch tested by independent labs for purity and potency.

  • Heavy Metals Screened

    Tested for lead, mercury, arsenic, and cadmium contamination.

  • Made in the USA

    Manufactured in the United States with globally sourced ingredients.

How to Use

Take 2 Capsules Daily

1

Split Your Dose

1 capsule with breakfast, 1 with dinner for sustained activity.

2

Take With Meals

Food improves absorption and maintains steady blood levels.

3

Allow 4-8 Weeks

Metabolic benefits build over time. Most see changes by week 8.*

Common Questions

Frequently Asked Questions

Is berberine really as effective as metformin?

Multiple studies have shown berberine can support healthy blood sugar levels comparably to metformin. However, berberine is a supplement, not a medication. If you're currently taking metformin or other blood sugar medications, consult your healthcare provider before adding berberine—do not replace prescribed medications without medical guidance.

Why split the dose instead of taking it all at once?

Berberine has a short half-life (about 4-5 hours), meaning it clears your system relatively quickly. Splitting your dose—one capsule with breakfast, one with dinner—maintains more consistent blood levels throughout the day for sustained AMPK activation.

What does "dual-source" mean?

We extract berberine from both the bark AND root of Berberis aristata (Indian barberry). Different plant parts contain slightly different alkaloid profiles. Combining both provides a broader spectrum of active compounds compared to single-source extracts.

Can I take berberine with other supplements?

Berberine pairs well with most supplements. It's often stacked with milk thistle for liver support or omega-3s for cardiovascular health. However, avoid taking it at the same time as medications—berberine can affect how your liver processes certain drugs. Space them 2-3 hours apart.

Will I experience any side effects?

Some people experience mild GI discomfort (cramping, diarrhea, or constipation) in the first week, especially at higher doses. Taking berberine with food significantly reduces this. If symptoms persist, try starting with one capsule daily and gradually increasing to the full dose.

Who should NOT take berberine?

Do not use if pregnant or nursing—berberine can cross the placenta. Avoid if taking blood thinners, immunosuppressants, or medications metabolized by the liver (CYP450 pathway). If you have low blood pressure or take blood sugar/cholesterol medications, consult your healthcare provider first.

4.6
Rated 4.6 out of 5 stars
Based on 179 reviews
Total 5 star reviews: 124 Total 4 star reviews: 47 Total 3 star reviews: 5 Total 2 star reviews: 2 Total 1 star reviews: 1
96%would recommend these products
179 reviews
  • Jeremy O.
    Verified Buyer
    Rated 5 out of 5 stars
    Doctor recommended

    My doctor who focuses on more holistic and natural alternatives to medicine advised me to take this years ago. I only now came across an advertisement for it a few months ago and gave it a shot. I can only say I can't believe I didn't do this sooner! I steadily weened off metformin (which was giving me side effects seemingly more headaches than I normally have every month since taking it years ago). Now I am off that. Berberine is a plant derivative. For me, no side effects! Can't say better things about this product and about this company. My doctor is also amazed at my controlled enzyme ranges and BG levels. Amazing!

  • James E.
    Verified Buyer
    Rated 5 out of 5 stars
    All the things you need to look for

    If you review, Berberine is effective but you look out for GMP and made in USA. Many are not. This one is.

  • Eleanor R.
    Verified Buyer
    Rated 5 out of 5 stars
    So good can't believe

    So effective I'm amazed! My blood sugar dropped by 17 points. My doctor asked me what I was doing after my last lab results came back so good. Fast effectiveness works almost immediately. Unbelievable !

  • Emily P.
    Verified Buyer
    Rated 5 out of 5 stars
    Superior results after latest labs

    Every week you notice something better. First it was better bowels. Then it's better energy every week, better! Talked to my doctor and they said it was ok for me to keep trying. Weeks later and my BG labs came back well within normal ranges! This is exactly what you are looking for if you want an herbal solution. I've recommended this to all my friends and family.

  • Elizabeth E.
    Verified Buyer
    Rated 5 out of 5 stars
    Absolute essential in medicine cabinet

    I take this religiously as my friend recommended me this for regulating my blood sugar levels. I've weened off metformin entirely because of berberine and feel so much better. This is an herbal alternative for me no side effects and I feel very safe. I've researched on this topic so much and there are so much misinformation that it may not work and yet here it is dropping my labs into normal ranges after stopping pharmacy drugs. I can't review berberine more highly and this company for introducing me to what it is!!

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